danaparoid
Sign in to saveAlso known as danaparoid sodium, Orgaran
Danaparoid sodium (Orgaran) is an anticoagulant with an antithrombotic action due to inhibition of thrombin generation (TGI) by two mechanisms: indirect inactivation of Factor Xa via AT and direct inhibition of thrombin activation of Factor IX (an important feedback loop for thrombin generation). It also possesses a minor anti-thrombin activity, mediated equally via AT and Heparin Co-factor II producing a ratio of anti-Xa:IIa activity >22. [Meuleman DG. Haemostasis 1992;22:58-65 and Ofosu FA Haemostasis 1992;22:66-72]
In the Vinony graph
Within Vinony's link graph, danaparoid is referenced by 120 other articles, and connects out to hirudin, coagulation factor X and ximelagatran.
It is catalogued under topics including Chemicals that do not have a ChemSpider ID assigned, Drugboxes which contain changes to verified fields and Drugs with no legal status.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Unknown
- First approval
- 1996
- Admin. routes
- parenteral
- Indications
- Recurrent thrombophlebitis, Thrombocytopenia
via ChEMBL · EBI
~4 min read
Encyclopedic overview
6 sectionsContents
- Uses
- Discontinuation
- Administration
- Side effects
- References
- External links
Danaparoid sodium (Orgaran) is an anticoagulant with an antithrombotic action due to inhibition of thrombin generation (TGI) by two mechanisms: indirect inactivation of Factor Xa via AT and direct inhibition of thrombin activation of Factor IX (an important feedback loop for thrombin generation). It also possesses a minor anti-thrombin activity, mediated equally via AT and Heparin Co-factor II producing a ratio of anti-Xa:IIa activity >22. [Meuleman DG. Haemostasis 1992;22:58-65 and Ofosu FA Haemostasis 1992;22:66-72]
Danaparoid is a low molecular weight heparinoid devoid of heparin. It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate. It is chemically distinct from heparin, has different protein-binding properties because of its low degree of sulphation and low surface charge density and thus has little cross-reactivity in heparin-intolerant patients.
Excerpted from Wikipedia’s “danaparoid” article, available under the CC BY-SA 4.0 licence.