DBX2
Sign in to saveAlso known as developing brain homeobox 2
Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene. DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain. The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.
Gene data
DBX2- Name
- developing brain homeobox 2
- Type
- protein-coding
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
developing brain homeobox 2
- Symbol
- DBX2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:45,011,945-45,051,105
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/440097
- HomoloGene ID
- 54981
- genomic end
- 45444882
- genomic start
- 45408455
- cytogenetic location
- 12q12
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Identification
- Associated diseases
- References
Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene. DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain. The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.
== Identification == Dbx (developing brain homeobox) was first isolated from a gestational day 13.5 mouse in 1992. There are two Dbx genes (DBX1 and DBX2) which are both important for development of the central nervous system. DBX2 shows conserved expression patterns in the developing brain and spinal cord and plays an important role in neural patterning and differentiation.