EMX2
Sign in to saveAlso known as empty spiracles homeobox 2
Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.
Gene data
EMX2- Name
- empty spiracles homeobox 2
- Type
- protein-coding
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009].
via MyGene.info
Wikidata facts
Show 3 more facts
- HomoloGene ID
- 3023
- exact match
- identifiers.org/ncbigene/2018
- cytogenetic location
- 10q26.11
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- See also
- References
- Further reading
- External links
Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.
== Function == The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head.[supplied by OMIM].