etomidat

Also known as Amidate®, D-etomidate, R 16659, (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester, (+)-ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate, R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate, (R)-(+)-1-(alpha-methylbenzyl)imidazole-5-carboxylic acid ethyl ester, (+)-etomidate

związek chemiczny

In the Vinony graph

Vinony's link graph records 908 inbound references to etomidat, and connects out to ginkgolide, benzodiazepine drug and picrotoxin.

It sits within the topics 11β-Hydroxylase inhibitors, Belgian inventions and Chemical substances for emergency medicine.

Vinony links it to 27 Wikipedia language editions.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 457797420
Drug.image: File:Etomidate.svg
Drug.image_class: skin-invert-image
Drug.caption: Above: molecular structure of (R)-etomidate Below: 3D representation of an etomidate molecule
Drug.image2: Etomidate 3D Ball-and-Stick.png
Drug.image_class2: bg-transparent
Drug.width: 150
Drug.tradename: Amidate, Hypnomidate, Tomvi
Drug.DailyMedID: Etomidate
Drug.routes_of_administration: Intravenous
Drug.ATC_prefix: N01
Drug.ATC_suffix: AX07
Drug.legal_AU: S4
Drug.legal_BR: C1
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_UK: POM

via Wikipedia infobox

Chemical data

Formula: C14H16N2O2
Molecular weight: 244.29 g/mol
IUPAC name: ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate
SMILES: CCOC(=O)C1=CN=CN1[C@H](C)C2=CC=CC=C2
InChIKey: NPUKDXXFDDZOKR-LLVKDONJSA-N
XLogP: 3
Polar surface area: 44.1 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: parenteral
Indications: hypertension, stroke, respiratory failure

via ChEMBL · EBI

Research

3,465 papers

Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients.American journal of respiratory and critical care medicine · 2024
Etomidate.Lancet (London, England) · 1983
Novel etomidate derivatives.Current pharmaceutical design · 2012
[Etomidate--propofol].Klinische Anasthesiologie und Intensivtherapie · 1993
Etomidate as an Induction Agent in Sepsis.Critical care nursing clinics of North America · 2018

via PubMed

Wikidata facts

Subclass of: heterocyclic compound
Has part: oxygen
Mass: 244.121178
Has use: medication

Show 7 more facts

medical condition treated: brain ischemia
Commons category: Etomidate
chemical formula: C₁₄H₁₆N₂O₂
route of administration: intravenous infusion and defusion
World Health Organisation international non-proprietary name: etomidate
isomeric SMILES: CCOC(=O)C1=CN=CN1[C@H](C)C2=CC=CC=C2
canonical SMILES: CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2

Sources (3)

via Wikidata · CC0

Article · Polski

Etomidat (łac. Etomidatum) – organiczny związek chemiczny, lek działający nasennie i przeciwdrgawkowo, stosowany do znieczulenia ogólnego. Wpływa silnie hamująco na twór siatkowaty w pniu mózgu. Pod względem chemicznym jest to pochodna imidazolowa.

Abstract from DBpedia / Wikipedia · CC BY-SA