FOXC2
Sign in to saveAlso known as FKHL14, LD, MFH-1, MFH1, forkhead box C2
Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.
In the Vinony graph
Vinony's link graph records 900 inbound references to FOXC2, and connects out to PubMed, homeobox and Ensembl genome database project.
It sits within the topics Forkhead transcription factors and Genes on human chromosome 16.
Vinony links it to 5 Wikipedia language editions.
Gene data
FOXC2- Name
- forkhead box C2
- Type
- protein-coding
- Position
- 86,566,829–86,569,728 (+)
- Aliases
- FKHL14, LD, MFH-1, MFH1
- Ensembl
- ENSG00000176692
- RefSeq RNA
- NM_005251.3
- RefSeq protein
- NP_005242.1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
forkhead box C2
- Symbol
- FOXC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:86,566,829-86,569,728
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 1d5v EBI.jpg
Show 8 more facts
- HomoloGene ID
- 21091
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2303
- genomic end
- 86602539
- genomic start
- 86566829
- chromosome
- human chromosome 16
- cytogenetic location
- 16q24.1
- genetic association
- Lymphedema–distichiasis syndrome
Sources (6)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Structure and function
- Role in disease
- References
- Further reading
- External links
Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.
==Structure and function== The protein is 501 amino acids in length. The gene has no introns; the single exon is approximately 1.5kb in size.
Excerpted from Wikipedia’s “FOXC2” article, available under the CC BY-SA 4.0 licence.