HOXA9
Sign in to saveAlso known as ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9, Homeobox protein Hox-A9, homeobox A9-like, LOC103692128
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.
Gene data
HOXA9- Name
- homeobox A9
- Type
- protein-coding
- Position
- 27,162,438–27,175,180 (−)
- Aliases
- ABD-B, HOX1, HOX1.7, HOX1G
- Ensembl
- ENSG00000078399
- RefSeq RNA
- NM_002142.3, NM_152739.4
- RefSeq protein
- NP_689952.1
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
homeobox A9
- Symbol
- HOXA9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:27,162,438-27,175,180
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~13 min read
Encyclopedic overview
13 sectionsContents
- Function
- Role in hematopoiesis
- Expression in adult, fetal and embryonic stages
- Clinical significance
- Role in acute myeloid leukemia
- Morphology alteration
- Pure erythroid leukemia
- Potential in Ovarian Cancer
- Interactions
- See also
- References
- Further reading
- External links
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila fly. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.
Excerpted from Wikipedia’s “HOXA9” article, available under the CC BY-SA 4.0 licence.