IKZF3

Name

IKAROS family zinc finger 3

Type

protein-coding

Position

39,757,715–39,864,368 (−)

Aliases

AIO, AIOLOS, IMD84, ZNFN1A3

Ensembl

ENSG00000161405

RefSeq RNA

NM_001257408.2, NM_001257409.2, NM_001257410.2, NM_001257411.2, NM_001257412.2

RefSeq protein

NP_001244337.1, NP_001244338.1, NP_001244339.1, NP_001244340.1, NP_001244341.1

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012].

via MyGene.info

Gene · Ensembl

IKAROS family zinc finger 3

Symbol

IKZF3

Biotype

Protein coding

Organism

Homo sapiens

Location

17:39,757,715-39,864,368

Strand

Reverse (−)

Assembly

GRCh38