Ломустин

Key facts

Drug.N

3

Drug.O

2

Drug.H

16

Drug.Cl

1

Drug.Verifiedfields

changed

Drug.Watchedfields

changed

Drug.verifiedrevid

462093427

Drug.IUPAC_name

N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea

Drug.image

Lomustine.svg

Drug.image_class

skin-invert-image

Drug.width

200

Drug.image2

Lomustine ball-and-stick model.png

Drug.image_class2

bg-transparent

Drug.width2

175

Drug.tradename

Gleostine, CCNU, CeeNu, CuuNu

Drug.MedlinePlus

a682207

Drug.pregnancy_US

D

Drug.legal_CA

Rx-only

via Wikipedia infobox

Chemical data

Formula

C9H16ClN3O2

Molecular weight

233.69 g/mol

IUPAC name

1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

SMILES

C1CCC(CC1)NC(=O)N(CCCl)N=O

InChIKey

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

XLogP

2.8

Polar surface area

61.8 Ų

H-bond donors

1

H-bond acceptors

3

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1976

Admin. routes

oral

Indications

neoplasm, glioblastoma multiforme, acute myeloid leukemia, anaplastic astrocytoma

via ChEMBL · EBI

• Lomustine and Bevacizumab in Progressive Glioblastoma.The New England journal of medicine · 2017
• Lomustine, methotrexate and cytarabine chemotherapy as a rescue treatment for feline lymphoma.Journal of feline medicine and surgery · 2021
• Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial.The Lancet. Oncology · 2019
• How did lomustine become standard of care in recurrent glioblastoma?Cancer treatment reviews · 2020
• Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.The Lancet. Oncology · 2014

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

233.093

Has use

medication

via Wikidata · CC0