menogaril
Sign in to saveMenogaril is an anthracycline analog of nogalamycin which was developed in late 1970s. It has even stronger anticancer activity, and less toxicity, than nogalamycin. However, its development for clinical use was cancelled due to only moderate success with relatively high incidence of serious toxicity (43-44% in non-Hodgkin's lymphoma patients).
Research
119 papers- Menogaril, an anthracycline compound with a novel mechanism of action: cellular pharmacology.Japanese journal of cancer research : Gann · 1990
- Pharmacokinetics and systemic bioavailability of menogaril, an anthracycline antitumor agent, in the mouse, dog, and monkey.Cancer research · 1989
- Menogaril: a new anthracycline agent entering clinical trials.Investigational new drugs · 1984
- Hepatocellular carcinoma. An ECOG randomized phase II study of beta-interferon and menogaril.American journal of clinical oncology · 1995
- The Uridylyl Transferase TUT7-Mediated Accumulation of Exosomal miR-1246 Reprograms TAMs to Support CRC Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
via PubMed
Wikidata facts
- Mass
- 541.195
Show 3 more facts
- chemical formula
- C₂₈H₃₁NO₁₀
- isomeric SMILES
- C[C@]1(CC2=CC3=C(C(=C2[C@@H](C1)OC)O)C(=O)C4=C(C=C5C(=C4C3=O)O[C@H]6[C@H]([C@@H]([C@H]([C@@]5(O6)C)O)N(C)C)O)O)O
- canonical SMILES
- CC1(CC2=CC3=C(C(=C2C(C1)OC)O)C(=O)C4=C(C=C5C(=C4C3=O)OC6C(C(C(C5(O6)C)O)N(C)C)O)O)O
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Article
1 sectionsContents
- References
Menogaril is an anthracycline analog of nogalamycin which was developed in late 1970s. It has even stronger anticancer activity, and less toxicity, than nogalamycin. However, its development for clinical use was cancelled due to only moderate success with relatively high incidence of serious toxicity (43-44% in non-Hodgkin's lymphoma patients).
== References ==
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