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GeneQ18034995· pop 5· linked from 822 articles

NR1H3

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Also known as LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3

protein-coding gene in the species Homo sapiens

Gene data

NR1H3

Name: nuclear receptor subfamily 1 group H member 3
Type: protein-coding
Position: 47,248,300–47,269,131 (+)
Aliases: LXR-a, LXRA, RLD-1
Ensembl: ENSG00000025434
RefSeq RNA: NM_001130101.3, NM_001130102.3, NM_001251934.2, NM_001251935.2, NM_001363595.2
RefSeq protein: NP_001123573.1, NP_001123574.1, NP_001238863.1, NP_001238864.1, NP_001350524.1

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription lipid metabolic process hormone-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

PPAR signaling pathway - Homo sapiens (human)Insulin resistance - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Metabolism Signal Transduction Plasma lipoprotein assembly, remodeling, and clearance PPARA activates gene expression Generic Transcription Pathway SUMOylation

via MyGene.info

Gene · Ensembl

nuclear receptor subfamily 1 group H member 3

Symbol: NR1H3
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:47,248,300-47,269,131
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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