PHF8

Name

PHD finger protein 8

Type

protein-coding

Chromosome

X

Position

53,934,245–54,048,958 (−)

Aliases

JHDM1F, KDM7B, MRXSSD, ZNF422

Ensembl

ENSG00000172943

RefSeq RNA

NM_001184896.1, NM_001184897.2, NM_001184898.2, NM_001441096.1, NM_001441097.1

RefSeq protein

NP_001171825.1, NP_001171826.1, NP_001171827.1, NP_001428025.1, NP_001428026.1

The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].

via MyGene.info

Gene · Ensembl

PHD finger protein 8

Symbol

PHF8

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr X:53,934,245-54,048,958

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein PHF8 PDB 2WWU.png

via Wikidata · CC0