RFXANK

Name

regulatory factor X associated ankyrin containing protein

Type

protein-coding

Position

19,191,957–19,202,844 (+)

Aliases

ANKRA1, BLS, F14150_1, MHC2D2, RFX-B

Ensembl

ENSG00000064490

RefSeq RNA

NM_001278727.2, NM_001278728.2, NM_001370233.1, NM_001370234.1, NM_001370235.1

RefSeq protein

NP_001265656.1, NP_001265657.1, NP_001357162.1, NP_001357163.1, NP_001357164.1

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

regulatory factor X associated ankyrin containing protein

Symbol

RFXANK

Biotype

Protein coding

Organism

Homo sapiens

Location

19:19,191,957-19,202,844

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0