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GeneQ18037084· pop 7· linked from 822 articles

SATB2

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Also known as GLSS, SATB homeobox 2

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei [https://www.proteinatlas.org/ENSG00000119042-SATB2/cell. The SATB2 protein is mainly expressed in the epithelial cells of the colon and rectum, followed by the nuclei of neurons in the brain.

Gene data

SATB2

Name: SATB homeobox 2
Type: protein-coding
Position: 199,269,484–199,471,266 (−)
Aliases: C2DELq32q33, DEL2Q32Q33, GLSS
Ensembl: ENSG00000119042
RefSeq RNA: NM_001172509.2, NM_001172517.1, NM_015265.4, NR_134967.2, XM_005246396.4
RefSeq protein: NP_001165980.1, NP_001165988.1, NP_056080.1, XP_005246453.1, XP_047299731.1

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010].

Gene Ontology

Biological process

chromatin remodeling chromatin remodeling regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

histone deacetylase complex chromatin nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex nuclear matrix

Pathways

Generic Transcription Pathway SUMOylation SUMO E3 ligases SUMOylate target proteins Metabolism of proteins SUMOylation of chromatin organization proteins Post-translational protein modification RNA Polymerase II Transcription Gene expression (Transcription)Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation

via MyGene.info

Gene · Ensembl

SATB homeobox 2

Symbol: SATB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:199,268,900-199,471,271
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 1wi3 EBI.jpg

Show 6 more facts

HomoloGene ID: 32249
exact match: identifiers.org/ncbigene/23314
genomic end: 200335989
genomic start: 200134223
cytogenetic location: 2q33.1
Commons category: DNA-binding protein SATB2

Sources (4)

via Wikidata · CC0

~4 min read

Article

6 sections

Contents

Function
Structure
Clinical significance
References
Further reading
External links

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei [https://www.proteinatlas.org/ENSG00000119042-SATB2/cell. The SATB2 protein is mainly expressed in the epithelial cells of the colon and rectum, followed by the nuclei of neurons in the brain.

== Function ==

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Categories

Genes on human chromosome 2 Transcription factors