ZBTB32
Sign in to saveAlso known as FAXF, FAZF, Rog, TZFP, ZNF538, zinc finger and BTB domain containing 32
Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.
Gene data
ZBTB32- Name
- zinc finger and BTB domain containing 32
- Type
- protein-coding
- Position
- 35,704,558–35,717,048 (+)
- Aliases
- FAXF, FAZF, Rog, TZFP, ZNF538, mynn
- Ensembl
- ENSG00000011590
- RefSeq RNA
- NM_001316902.2, NM_001316903.2, NM_014383.3, XM_017026591.2, XM_054320531.1
- RefSeq protein
- NP_001303831.1, NP_001303832.1, NP_055198.1, XP_016882080.1, XP_054176506.1
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
zinc finger and BTB domain containing 32
- Symbol
- ZBTB32
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:35,704,558-35,717,048
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Encyclopedic overview
7 sectionsContents
- Nomenclature
- Interactions
- Immune system
- Cancer
- References
- Further reading
- External links
Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.
The protein recruits histone modification enzymes to chromatin to affect gene activation. ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1, to suppress the transcription of genes .
Excerpted from Wikipedia’s “ZBTB32” article, available under the CC BY-SA 4.0 licence.