antazoline

Also known as 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine, 2-(N-Benzylanilinomethyl)-2-imidazoline, 2-(N-Phenyl-N-benzylaminomethyl)imidazoline

Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline. The drug is a Histamine H1 receptor antagonist: selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

Key facts

Drug.image: Antazoline.svg
Drug.image_class: skin-invert-image
Drug.width: 215
Drug.tradename: Vasocon-a
Drug.routes_of_administration: Topical (nasal, eye drops)
Drug.ATC_prefix: R01
Drug.ATC_suffix: AC04
Drug.legal_AU: S4
Drug.legal_AU_comment: /Schedule 2
Drug.CAS_number: 91-75-8
Drug.PubChem: 2200
Drug.IUPHAR_ligand: 7116
Drug.DrugBank: DB08799
Drug.ChemSpiderID: 2115
Drug.UNII: DHA8014SS1
Drug.KEGG: D07458
Drug.ChEBI: 84115
Drug.ChEMBL: 1305

via Wikipedia infobox

Research

325 papers

Antazoline: the Lazarus of antiarrhythmic drugs?Polish archives of internal medicine · 2022
Effectiveness of antazoline versus amiodarone, flecainide and propafenone in restoring sinus rhythm at the emergency department.Advances in medical sciences · 2024
Intravenous antazoline, a first-generation antihistaminic drug with antiarrhythmic properties, is a suitable agent for pharmacological cardioversion of atrial fibrillation induced during pulmonary vein isolation due to the lack of influence on atrio-venous conduction and high clinical effectiveness (AntaEP Study).British journal of clinical pharmacology · 2019
Antazoline for pharmacologic cardioversion of atrial fibrillation: teaching an old drug new tricks.Polish archives of internal medicine · 2024
Efficacy and safety of antazoline vs propafenone for conversion of paroxysmal atrial fibrillation to sinus rhythm: a randomized, double-blind study (AnProAF).Polish archives of internal medicine · 2024

via PubMed

Wikidata facts

Mass: 265.157898

Show 4 more facts

chemical formula: C₁₇H₁₉N₃
canonical SMILES: C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3
World Health Organisation international non-proprietary name: antazoline
Commons category: Antazoline

Sources (2)

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Article

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Contents

Research
References

== Research == A 2015 study on people aged 65 years of age or older linked the development of Alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their anticholinergic properties.