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GeneQ18045804· pop 8· linked from 822 articles

BCL11B

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Also known as ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.

Gene data

BCL11B
Name
BCL11 transcription factor B
Type
protein-coding
Position
99,169,287–99,272,197 (−)
Aliases
ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, IDDFSTA, IMD49, RIT1
Ensembl
ENSG00000127152
RefSeq RNA
NM_001282237.2, NM_001282238.2, NM_022898.3, NM_138576.4, XM_047431707.1
RefSeq protein
NP_001269166.1, NP_001269167.1, NP_075049.1, NP_612808.1, XP_047287663.1

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013].

Gene Ontology

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)Chromatin organizationChromatin organizationATP-dependent chromatin remodelersATP-dependent chromatin remodelersSWI/SNF chromatin remodelersSWI/SNF chromatin remodelersFormation of the embryonic stem cell BAF (esBAF) complexFormation of neuronal progenitor and neuronal BAF (npBAF and nBAF)Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)

via MyGene.info

Gene · Ensembl

BCL11 transcription factor B

Symbol
BCL11B
Biotype
Protein coding
Organism
Homo sapiens
Location
14:99,169,287-99,272,197
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
10974
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/64919
genomic end
99272197
genomic start
99635624
chromosome
human chromosome 14
cytogenetic location
14q32.2
expressed in
gums
Sources (3)

via Wikidata · CC0

~3 min read

Encyclopedic overview

8 sections
Contents
  • Gene location
  • Function
  • Interactions
  • Pathology
  • Research projects
  • References
  • Further reading
  • External links

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.

== Gene location == BCL11B is located on human chromosome 14p32.2. The mouse analogue is called Rit1 or Bcl11b and is located on mouse chromosome 12.

Excerpted from Wikipedia’s “BCL11B” article, available under the CC BY-SA 4.0 licence.

Available in 8 languages

via Wikidata sitelinks · CC0