bendazac

Also known as bendazolic acid, EINECS 243-569-2, UNII-G4AG71204O, BRN 0893958

Bendazac (or bendazolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.

In the Vinony graph

Vinony's link graph records 287 inbound references to bendazac, and connects out to salicylic acid, non-steroidal anti-inflammatory drug and metamizole sodium.

It is catalogued under topics including Chemical pages without DrugBank identifier, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.

Vinony links it to 10 Wikipedia language editions.

Chemical data

Formula: C16H14N2O3
Molecular weight: 282.29 g/mol
IUPAC name: 2-(1-benzylindazol-3-yl)oxyacetic acid
SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O
InChIKey: BYFMCKSPFYVMOU-UHFFFAOYSA-N
XLogP: 3.1
Polar surface area: 64.4 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1984
Indications: eye inflammation, Myalgia, Arthralgia

via ChEMBL · EBI

Research

111 papers

Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts.Drugs · 1990
Potential Application of Bendazac L-Lysine for Controlling Myopia Progression, as Demonstrated in Two Experimental Guinea Pig Myopia Models.Investigative ophthalmology & visual science · 2025
Allergic contact dermatitis due to bendazac and alclometasone dipropionate.Contact dermatitis · 1999
Pharmacokinetics of bendazac-lysine and 5-hydroxybendazac in patients with renal insufficiency.European journal of clinical pharmacology · 1987
Bendazac lysine in selected types of human senile cataract. A long-term double-masked placebo-controlled clinical trial with multilinear densitometric image analysis of Scheimpflug photographs.Ophthalmic research · 1989

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 282.1

Show 4 more facts

canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O
chemical formula: C₁₆H₁₄N₂O₃
World Health Organisation international non-proprietary name: bendazac
subject has role: non-steroidal anti-inflammatory drug

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Synthesis
See also
References

Bendazac (or bendazolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.

==Synthesis== Principal action is inhibition of protein denaturation. class=skin-invert-image|thumb|center|700px|Bendazac synthesis: ; G. Palazzo, (1967, 1969 both to Francesco Angelini). Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine).

Excerpted from Wikipedia’s “bendazac” article, available under the CC BY-SA 4.0 licence.