BHLHE41
Sign in to saveAlso known as BHLHB3, DEC2, SHARP1, HDEC2, SHARP-1, Basic Helix-Loop-Helix Family Member E41, Basic Helix-Loop-Helix Family, Member E41
"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.
Gene data
BHLHE41- Name
- basic helix-loop-helix family member e41
- Type
- protein-coding
- Position
- 26,117,178–26,125,106 (−)
- Aliases
- BHLHB3, DEC2, FNSS1, SHARP1, hDEC2
- Ensembl
- ENSG00000123095
- RefSeq RNA
- NM_030762.3, XM_054373204.1
- RefSeq protein
- NP_110389.1, XP_054229179.1
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
basic helix-loop-helix family member e41
- Symbol
- BHLHE41
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:26,117,178-26,125,106
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~10 min read
Encyclopedic overview
17 sectionsContents
- History
- Structure
- Function
- Circadian
- Non-circadian
- Mutations
- DEC2-P385R
- BHLHE41 knockout
- Clinical significance
- Immune system
- Hypoxia
- Muscle
- Sarcoma, oral cancer, liver cancer, and colon cancer
- Breast cancer
- References
- Further reading
- External links
"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.
== History ==
Excerpted from Wikipedia’s “BHLHE41” article, available under the CC BY-SA 4.0 licence.