C-X-C motif chemokine ligand 16

Also known as SR-PSOX, C-X-C motif chemokine 16, chemokine (C-X-C motif) ligand 16, CXCL16, CXC chemokine ligand 16, small-inducible cytokine B16, transmembrane chemokine CXCL16, scavenger receptor for phosphatidylserine and oxidized low density lipoprotein

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Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.

These are unusual features for a chemokine, allowing CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine. CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.