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GeneQ17912234· pop 5· linked from 298 articles

CYP51A1

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Also known as CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1, cytochrome P450 family 51 subfamily A member 1

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 298 inbound references to CYP51A1, and connects out to PubMed, Online Mendelian Inheritance in Man and UniProt.

It sits within the topics Cytochrome P450, EC 1.14.14 and Enzymes of known structure.

Vinony links it to 5 Wikipedia language editions.

Gene data

CYP51A1

Name: cytochrome P450 family 51 subfamily A member 1
Type: protein-coding
Position: 92,084,502–92,134,803 (−)
Aliases: CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Ensembl: ENSG00000001630
RefSeq RNA: NM_000786.4, NM_001146152.2
RefSeq protein: NP_000777.1, NP_001139624.1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Gene Ontology

Biological process

steroid biosynthetic process cholesterol biosynthetic process cholesterol biosynthetic process sterol metabolic process zymosterol biosynthetic process negative regulation of protein catabolic process negative regulation of protein catabolic process negative regulation of protein secretion

Molecular function

monooxygenase activity iron ion binding sterol 14-demethylase activity sterol 14-demethylase activity sterol 14-demethylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Cellular component

endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane membrane

Pathways

Steroid biosynthesis - Homo sapiens (human)Developmental Biology Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Cholesterol biosynthesis Biological oxidations Cytochrome P450 - arranged by substrate type Phase I - Functionalization of compounds Endogenous sterols Activation of gene expression by SREBF (SREBP)

via MyGene.info

Gene · Ensembl

cytochrome P450 family 51 subfamily A member 1

Symbol: CYP51A1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:92,084,502-92,134,803
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 55488
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1595
genomic end: 92134803
genomic start: 92084987
chromosome: human chromosome 7
cytogenetic location: 7q21.2
expressed in: superior frontal gyrus

Sources (4)

via Wikidata · CC0

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via Wikidata sitelinks · CC0

Categories

Cytochrome P450 EC 1.14.14 Enzymes of known structure Genes on human chromosome 7 NADPH-dependent enzymes Protein pages needing a picture