fluvastatin

Also known as XUO320, Canef®, Lescol®, (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, (+)-(3R,5S)-fluvastatin

Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.

In the Vinony graph

Within Vinony's link graph, fluvastatin is referenced by 108 other articles, and connects out to World Health Organization, liver and medication.

It sits within the topics 4-Fluorophenyl compounds, Carboxylic acids and CYP2C9 inhibitors.

Its subject is documented across 22 Wikipedia language editions.

Chemical data

Formula: C24H26FNO4
Molecular weight: 411.5 g/mol
IUPAC name: (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
InChIKey: FJLGEFLZQAZZCD-MCBHFWOFSA-N
XLogP: 3.5
Polar surface area: 82.7 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Research

2,370 papers

Fluvastatin: A Choice for COVID-19-associated Mucormycosis Management.Current medicinal chemistry · 2024
Fluvastatin for lowering lipids.The Cochrane database of systematic reviews · 2018
Fluvastatin.Expert opinion on pharmacotherapy · 2002
Clinical pharmacokinetics of fluvastatin.Clinical pharmacokinetics · 2001
Fluvastatin treatment is not associated with an increased incidence of cancer.International journal of clinical practice · 2006

via PubMed

Wikidata facts

Mass: 411.185
Has use: medication

Show 9 more facts

significant drug interaction: bezafibrate
chemical formula: C₂₄H₂₆FNO₄
defined daily dose: 60
medical condition treated: hypercholesterolemia
canonical SMILES: CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F
isomeric SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
World Health Organisation international non-proprietary name: fluvastatin
Commons category: Fluvastatin
physically interacts with: 3-hydroxy-3-methylglutaryl-CoA reductase