FZD7
Sign in to saveAlso known as FzE3, frizzled class receptor 7
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.
Gene data
FZD7- Name
- frizzled class receptor 7
- Type
- protein-coding
- Position
- 202,033,855–202,038,441 (+)
- Aliases
- FzE3
- Ensembl
- ENSG00000155760
- RefSeq RNA
- NM_003507.2
- RefSeq protein
- NP_003498.1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
frizzled class receptor 7
- Symbol
- FZD7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:202,033,855-202,038,441
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 20751
- exact match
- identifiers.org/ncbigene/8324
- genomic end
- 202038441
- genomic start
- 202033855
- cytogenetic location
- 2q33.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.