FZD7
Sign in to saveAlso known as FzE3, frizzled class receptor 7
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.
In the Vinony graph
Vinony's link graph records 488 inbound references to FZD7, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
It sits within the topics Genes on human chromosome 2 and G protein-coupled receptors.
Vinony links it to 7 Wikipedia language editions.
Gene data
FZD7- Name
- frizzled class receptor 7
- Type
- protein-coding
- Position
- 202,033,855–202,038,441 (+)
- Aliases
- FzE3
- Ensembl
- ENSG00000155760
- RefSeq RNA
- NM_003507.2
- RefSeq protein
- NP_003498.1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
frizzled class receptor 7
- Symbol
- FZD7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:202,033,855-202,038,441
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 20751
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8324
- genomic end
- 202038441
- genomic start
- 202033855
- chromosome
- human chromosome 2
- cytogenetic location
- 2q33.1
- expressed in
- seminal vesicula
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Excerpted from Wikipedia’s “FZD7” article, available under the CC BY-SA 4.0 licence.