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GeneQ18026903· pop 6· linked from 811 articles

HIVEP1

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Also known as CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

Gene data

HIVEP1
Name
HIVEP zinc finger 1
Type
protein-coding
Position
12,008,762–12,164,999 (+)
Aliases
CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A
Ensembl
ENSG00000095951
RefSeq RNA
NM_002114.4, XM_011514548.3, XM_011514552.3, XM_011514553.2, XM_011514555.4
RefSeq protein
NP_002105.3, XP_011512850.1, XP_011512854.1, XP_011512855.1, XP_011512857.1

This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011].

Gene Ontology

via MyGene.info

Gene · Ensembl

HIVEP zinc finger 1

Symbol
HIVEP1
Biotype
Protein coding
Organism
Homo sapiens
Location
6:12,008,762-12,164,999
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • Further reading
  • External links

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Excerpted from Wikipedia’s “HIVEP1” article, available under the CC BY-SA 4.0 licence.

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