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GeneQ18027445· pop 8· linked from 1,842 articles

HTR5A

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Also known as 5-HT5A, 5-HT5A receptor, 5-hydroxytryptamine receptor 5A

protein-coding gene in the species Homo sapiens

Gene data

HTR5A

Name: 5-hydroxytryptamine receptor 5A
Type: protein-coding
Position: 155,070,324–155,087,392 (+)
Aliases: 5-HT5A
Ensembl: ENSG00000157219
RefSeq RNA: NM_024012.4, XR_008487586.1
RefSeq protein: NP_076917.1

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting serotonin receptor signaling pathway adenylate cyclase-inhibiting serotonin receptor signaling pathway chemical synaptic transmission hippocampus development

Molecular function

Gi/o-coupled serotonin receptor activity Gi/o-coupled serotonin receptor activity G protein-coupled receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity protein binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane dendrite dendrite perikaryon

Pathways

Calcium signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Amine ligand-binding receptors GPCR downstream signalling Serotonin receptors G alpha (i) signalling events

via MyGene.info

Gene · Ensembl

5-hydroxytryptamine receptor 5A

Symbol: HTR5A
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:155,070,319-155,087,392
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 22461
exact match: identifiers.org/ncbigene/3361
genomic end: 155087392
genomic start: 154862034
cytogenetic location: 7q36.2

Sources (5)

via Wikidata · CC0

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 7 Serotonin receptors