MED1

Also known as CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.

In the Vinony graph

Vinony's link graph records 59 inbound references to MED1, and connects out to PubMed, Ensembl genome database project and mediator complex.

It sits within the topics Genes on human chromosome 17, Protein domains and Protein pages needing a picture.

Vinony links it to 4 Wikipedia language editions.

Gene data

MED1

Name: mediator complex subunit 1
Type: protein-coding
Position: 39,404,253–39,451,306 (−)
Aliases: CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Ensembl: ENSG00000125686
RefSeq RNA: NM_004774.4, XM_006721957.3, XM_047436314.1, XM_047436315.1, XM_054316538.1
RefSeq protein: NP_004765.2, XP_006722020.1, XP_047292270.1, XP_047292271.1, XP_054172513.1

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008].