MED1

Name

mediator complex subunit 1

Type

protein-coding

Aliases

CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

mediator complex subunit 1

Symbol

MED1

Biotype

Protein coding

Organism

Homo sapiens

Location

17:39,404,253-39,451,306

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

The IDRc bound human core Mediator complex - Mediator of RNA polymerase II transcription subunit 1 (2) 8TRH.png

via Wikidata · CC0