MTF1
Sign in to saveAlso known as MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.
Gene data
MTF1- Name
- metal regulatory transcription factor 1
- Type
- protein-coding
- Position
- 37,809,574–37,859,614 (−)
- Aliases
- MTF-1, ZRF
- Ensembl
- ENSG00000188786
- RefSeq RNA
- NM_005955.3, XM_011541491.3, XM_011541493.4, XM_047421170.1, XM_047421173.1
- RefSeq protein
- NP_005946.2, XP_011539793.1, XP_011539795.1, XP_047277126.1, XP_047277129.1
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 4347
- genetic association
- hypothyroidism
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4520
- genomic end
- 37859592
- genomic start
- 37809574
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.3
- expressed in
- gums
via Wikidata · CC0
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Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.
== Function ==
Excerpted from Wikipedia’s “MTF1” article, available under the CC BY-SA 4.0 licence.