NKX6-2

Also known as GTX, NKX6.2, NKX6B, NK6 homeobox 2, SPAX8

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.

In the Vinony graph

Vinony's link graph records 814 inbound references to NKX6-2, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Vinony links it to 5 Wikipedia language editions.

Gene data

NKX6-2

Name: NK6 homeobox 2
Type: protein-coding
Position: 132,783,179–132,786,149 (−)
Aliases: GTX, NKX6.2, NKX6B, SPAX8
Ensembl: ENSG00000148826
RefSeq RNA: NM_177400.3, XM_054366950.1
RefSeq protein: NP_796374.2, XP_054222925.1

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation; regulation of myelination; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; neurogenesis; and neuromuscular process controlling balance. Predicted to be part of chromatin. Predicted to be active in nucleus. Implicated in spastic ataxia 8. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II cell differentiation regulation of myelination regulation of myelination negative regulation of DNA-templated transcription

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus

via MyGene.info

Gene · Ensembl

NK6 homeobox 2

Symbol: NKX6-2
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:132,783,179-132,786,149
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 18580
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84504
genomic end: 132786147
genomic start: 134598297
chromosome: human chromosome 10
cytogenetic location: 10q26.3
expressed in: caudate nucleus

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Tissue distribution
Function
Clinical significance
Research
References

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.

Nk6 homeobox 2 gene (Nkx6.2) is found on chromosome 10 in humans and on chromosome 7 in murine species. Expression of the Nkx6.2 gene results in the Nkx6.2 transcription factor.

Excerpted from Wikipedia’s “NKX6-2” article, available under the CC BY-SA 4.0 licence.