PROP1

Also known as CPHD2, PROP-1, PROP paired-like homeobox 1

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.

Gene data

PROP1

Name: PROP paired-like homeobox 1
Type: protein-coding
Chromosome: HSCHR5_2_CTG5
Position: 130,718–131,530 (−)
Aliases: CPHD2, PROP-1
Ensembl: ENSG00000175325
RefSeq RNA: NM_006261.5
RefSeq protein: NP_006252.4

This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

Article

3 sections

Contents

References
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External links

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.

PROP1 has both DNA-binding and transcriptional activation ability. Its expression leads to ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes, and caudomedial thyrotropes. Inactivating mutations in PROP1 result in deficiencies of luteinizing hormone (LH; MIM 152780), follicle-stimulating hormone (FSH; MIM 136530), growth hormone (GH; MIM 139250), prolactin (PRL; MIM 176760), and thyroid-stimulating hormone (TSH; MIM 188540). See combined pituitary hormone deficiency (CPHD; MIM 262600).[supplied by OMIM]