Structure via PubChem · Public domain (PubChem)
quinupramine
Sign in to saveQuinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.
In the Vinony graph
Within Vinony's link graph, quinupramine is referenced by 721 other articles, and connects out to propranolol, N-methylserotonin and atropine.
It is catalogued under topics including Chemical pages without DrugBank identifier, Dibenzazepines and Drugs with non-standard legal status.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C21H24N2
- Molecular weight
- 304.4 g/mol
- IUPAC name
- 11-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydrobenzo[b][1]benzazepine
- SMILES
- C1CN2CCC1C(C2)N3C4=CC=CC=C4CCC5=CC=CC=C53
- InChIKey
- JCBQCKFFSPGEDY-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.194
Show 2 more facts
- chemical formula
- C₂₁H₂₄N₂
- canonical SMILES
- C1CN2CCC1C(C2)N3C4=CC=CC=C4CCC5=CC=CC=C53
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.
Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.
Excerpted from Wikipedia’s “quinupramine” article, available under the CC BY-SA 4.0 licence.