Structure via PubChem · Public domain (PubChem)
quinupramine
Sign in to saveQuinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.
Chemical data
- Formula
- C21H24N2
- Molecular weight
- 304.4 g/mol
- IUPAC name
- 11-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydrobenzo[b][1]benzazepine
- SMILES
- C1CN2CCC1C(C2)N3C4=CC=CC=C4CCC5=CC=CC=C53
- InChIKey
- JCBQCKFFSPGEDY-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.194
Show 2 more facts
- chemical formula
- C₂₁H₂₄N₂
- canonical SMILES
- C1CN2CCC1C(C2)N3C4=CC=CC=C4CCC5=CC=CC=C53
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.
Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.
Excerpted from Wikipedia’s “quinupramine” article, available under the CC BY-SA 4.0 licence.