SSH2

Also known as SSH-2, SSH-2L, slingshot protein phosphatase 2

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

Gene data

SSH2

Name: slingshot protein phosphatase 2
Type: protein-coding
Aliases: SSH-2, SSH-2L

This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

via MyGene.info

Gene · Ensembl

slingshot protein phosphatase 2

Symbol: SSH2
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:29,625,938-29,930,276
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SSH2 PDB 2nt2.png

Show 5 more facts

HomoloGene ID: 14116
exact match: identifiers.org/ncbigene/85464
genomic end: 28257294
genomic start: 27952956
cytogenetic location: 17q11.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

References
Further reading
External links

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]