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GeneQ14905267· pop 7· linked from 505 articles

TRHR

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Also known as TRH-R, thyrotropin releasing hormone receptor, CHNG7

protein-coding gene in the species Homo sapiens

Gene data

TRHR

Name: thyrotropin releasing hormone receptor
Type: protein-coding
Position: 109,086,585–109,121,565 (+)
Aliases: CHNG7, TRH-R
Ensembl: ENSG00000174417
RefSeq RNA: NM_003301.7
RefSeq protein: NP_003292.1

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular function

G protein-coupled receptor activity thyrotropin-releasing hormone receptor activity thyrotropin-releasing hormone receptor activity thyrotropin-releasing hormone receptor activity protein binding

Cellular component

plasma membrane plasma membrane plasma membrane membrane

Pathways

Calcium signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptors GPCR downstream signalling G alpha (q) signalling events GPCR ligand binding Peptide GPCRs

via MyGene.info

Gene · Ensembl

thyrotropin releasing hormone receptor

Symbol: TRHR
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:109,086,585-109,121,565
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 20707
exact match: identifiers.org/ncbigene/7201
genomic end: 109121565
genomic start: 109086585
cytogenetic location: 8q23.1

Sources (6)

via Wikidata · CC0

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 8 G protein-coupled receptors