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GeneQ18032405· pop 9· linked from 842 articles

YY1

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Also known as DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS

YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene.

In the Vinony graph

Within Vinony's link graph, YY1 is referenced by 842 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

It sits within the topics Genes on human chromosome 14 and Transcription factors.

Its subject is documented across 9 Wikipedia language editions.

Gene data

YY1

Name: YY1 transcription factor
Type: protein-coding
Position: 100,238,298–100,282,788 (+)
Aliases: DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1
Ensembl: ENSG00000100811
RefSeq RNA: NM_003403.5
RefSeq protein: NP_003394.1

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II telomere maintenance double-strand break repair via homologous recombination regulation of DNA replication regulation of DNA repair chromatin remodeling

Molecular function

four-way junction DNA binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding

Cellular component

chromatin chromatin fibrillar center nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Developmental Biology Signal Transduction Generic Transcription Pathway Metabolism of proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Activation of HOX genes during differentiation Deubiquitination UCH proteinases DNA Damage Recognition in GG-NER Nucleotide Excision Repair

via MyGene.info

Gene · Ensembl

YY1 transcription factor

Symbol: YY1
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:100,238,298-100,282,788
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein YY1 PDB 1ubd.png

Show 7 more facts

HomoloGene ID: 2556
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7528
genomic end: 100282788
genomic start: 100704635
chromosome: human chromosome 14
cytogenetic location: 14q32.2

Sources (5)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
Interactions
References
Further reading
External links

YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene.

== Function ==

Excerpted from Wikipedia’s “YY1” article, available under the CC BY-SA 4.0 licence.

Available in 9 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 14 Transcription factors