aliskiren
Also known as SPP100, CGP-060536B, SPP 100
Aliskiren (brand names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. It is used for essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.
Chemical data
- Formula
- C30H53N3O6
- Molecular weight
- 551.8 g/mol
- IUPAC name
- (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
- SMILES
- CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N
- InChIKey
- UXOWGYHJODZGMF-QORCZRPOSA-N
- XLogP
- 3.5
- Polar surface area
- 146 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
1,364 papers~7 min read
Article
9 sectionsContents
- Medical uses
- Adverse effects
- Contraindications
- Drug interactions
- Mechanism of action
- Chemistry
- Rationale for design
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 477317502 | IUPAC_name = (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide | image = Aliskiren.svg | image_class = skin-invert-image | width = 275
| tradename = Tekturna, Rasilez | Drugs.com = | MedlinePlus = a607039 | DailyMedID = Aliskiren | licence_EU = yes | licence_US = Tekturna | pregnancy_AU = | pregnancy_US = | pregnancy_category = C in first trimesterD in second and third trimesters | legal_AU = | legal_CA = | legal_UK = POM | legal_US = Rx-only | routes_of_administration = By mouth (tablets)