BGN

Also known as DSPG1, PG-S1, PGI, SLRR1A, biglycan, SEMDX, MRLS

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome.

Gene data

BGN

Name: biglycan
Type: protein-coding
Chromosome: X
Aliases: DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

biglycan

Symbol: BGN
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:153,488,654-153,510,711
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein BGN PDB 2ft3.png

Show 5 more facts

HomoloGene ID: 1293
exact match: identifiers.org/ncbigene/633
genomic start: 153494980
genomic end: 153509546
cytogenetic location: Xq28

Sources (7)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Structure
Function
Interactions
References
External links

The name "biglycan" was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I).