Also known as complement component 7, complement C7
protein-coding gene in the species Homo sapiens
In the Vinony graph
Within Vinony's link graph, C7 is referenced by 67 other articles, and connects out to human chromosome 5, Ensembl genome database project and protein.
It is catalogued under topics including Complement system and Genes on human chromosome 5.
Its subject is documented across 7 Wikipedia language editions.
Gene data
C7- Name
- complement C7
- Type
- protein-coding
- Position
- 40,909,416–41,020,216 (+)
- Ensembl
- ENSG00000112936
- RefSeq RNA
- NM_000587.4
- RefSeq protein
- NP_000578.2
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
complement C7
- Symbol
- C7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:40,909,416-41,020,216
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 489
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/730
- genomic end
- 40984643
- genomic start
- 40909492
- chromosome
- human chromosome 5
- cytogenetic location
- 5p13.1
- different from
- C7
- expressed in
- right coronary artery
via Wikidata · CC0