MXD1

Also known as BHLHC58, MAD, MAD1, MAX dimerization protein 1

MAD protein is a protein that in humans is encoded by the MXD1 gene.

In the Vinony graph

Vinony's link graph records 816 inbound references to MXD1, and connects out to PubMed, homeobox and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Vinony links it to 6 Wikipedia language editions.

Gene data

MXD1

Name: MAX dimerization protein 1
Type: protein-coding
Position: 69,897,688–69,942,945 (+)
Aliases: BHLHC58, MAD, MAD1
Ensembl: ENSG00000059728
RefSeq RNA: NM_001202513.2, NM_001202514.2, NM_002357.4
RefSeq protein: NP_001189442.1, NP_001189443.1, NP_002348.1

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding protein dimerization activity

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus Mad-Max complex RNA polymerase II transcription repressor complex

Pathways

Vitamin D Receptor Pathway Pre-implantation embryo

via MyGene.info

Gene · Ensembl

MAX dimerization protein 1

Symbol: MXD1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:69,897,688-69,942,945
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MXD1 PDB 1nlw.png

Show 7 more facts

HomoloGene ID: 1767
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4084
genomic end: 70170077
genomic start: 70124820
chromosome: human chromosome 2
cytogenetic location: 2p13.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
References
Further reading
External links

MAD protein is a protein that in humans is encoded by the MXD1 gene.

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.

Excerpted from Wikipedia’s “MXD1” article, available under the CC BY-SA 4.0 licence.