MXD1

Also known as BHLHC58, MAD, MAD1, MAX dimerization protein 1

MAD protein is a protein that in humans is encoded by the MXD1 gene.

Gene data

MXD1

Name: MAX dimerization protein 1
Type: protein-coding
Position: 69,897,688–69,942,945 (+)
Aliases: BHLHC58, MAD, MAD1
Ensembl: ENSG00000059728
RefSeq RNA: NM_001202513.2, NM_001202514.2, NM_002357.4
RefSeq protein: NP_001189442.1, NP_001189443.1, NP_002348.1

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

~1 min read

Article

4 sections

Contents

Interactions
References
Further reading
External links

MAD protein is a protein that in humans is encoded by the MXD1 gene.

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.