NRAS
Sign in to saveAlso known as ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
protein-coding gene in the species Homo sapiens
Gene data
NRAS- Name
- NRAS proto-oncogene, GTPase
- Type
- protein-coding
- Position
- 114,704,469–114,716,771 (−)
- Aliases
- ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, RALD1
- Ensembl
- ENSG00000213281
- RefSeq RNA
- NM_002524.5
- RefSeq protein
- NP_002515.1
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NRAS proto-oncogene, GTPase
- Symbol
- NRAS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:114,704,468-114,716,775
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NRAS PDB 121p.png
Show 6 more facts
- exact match
- identifiers.org/ncbigene/4893
- HomoloGene ID
- 55661
- genomic end
- 114716771
- genomic start
- 115247090
- cytogenetic location
- 1p13.2
- Commons category
- Neuroblastoma RAS viral oncogene homolog
Sources (7)
via Wikidata · CC0