NRAS
Sign in to saveAlso known as ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
protein-coding gene in the species Homo sapiens
In the Vinony graph
Within Vinony's link graph, NRAS is referenced by 333 other articles, and connects out to PubMed, Ensembl genome database project and translation elongation factor.
It is catalogued under topics including Genes on human chromosome 1 and Oncogenes.
Its subject is documented across 4 Wikipedia language editions.
Gene data
NRAS- Name
- NRAS proto-oncogene, GTPase
- Type
- protein-coding
- Position
- 114,704,468–114,716,775 (−)
- Aliases
- ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, RALD1
- Ensembl
- ENSG00000213281
- RefSeq RNA
- NM_002524.5
- RefSeq protein
- NP_002515.1
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NRAS proto-oncogene, GTPase
- Symbol
- NRAS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:114,704,468-114,716,775
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NRAS PDB 121p.png
Show 9 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4893
- HomoloGene ID
- 55661
- genomic end
- 114716771
- genomic start
- 115247090
- chromosome
- human chromosome 1
- cytogenetic location
- 1p13.2
- genetic association
- melanoma
- Commons category
- Neuroblastoma RAS viral oncogene homolog
Sources (7)
via Wikidata · CC0