English

English Deutsch Español Français Italiano Nederlands Português Svenska

GeneQ18037544· pop 5· linked from 487 articles

NTSR2

Sign in to save

Also known as NTR2, Neurotensin receptor 2

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 487 inbound references to NTSR2, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

Vinony files it under Genes on human chromosome 2 and G protein-coupled receptors.

Vinony links it to 5 Wikipedia language editions.

Gene data

NTSR2

Name: neurotensin receptor 2
Type: protein-coding
Position: 11,658,161–11,670,346 (−)
Aliases: NTR2
Ensembl: ENSG00000169006
RefSeq RNA: NM_012344.4, XM_005246156.4, XM_006711876.5, XM_006711877.4, XM_017003738.2
RefSeq protein: NP_036476.2, XP_005246213.1, XP_006711939.1, XP_006711940.1, XP_016859227.1

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

cell surface receptor signaling pathway G protein-coupled receptor signaling pathway neuropeptide signaling pathway sensory perception

Molecular function

G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled neurotensin receptor activity G protein-coupled neurotensin receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane membrane

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptors GPCR downstream signalling G alpha (q) signalling events GPCR ligand binding Peptide GPCRs GPCRs, Class A Rhodopsin-like

via MyGene.info

Gene · Ensembl

neurotensin receptor 2

Symbol: NTSR2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:11,658,161-11,670,346
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

found in taxon: Homo sapiens
HomoloGene ID: 7452
exact match: identifiers.org/ncbigene/23620
genomic end: 11670195
genomic start: 11798304
chromosome: human chromosome 2
cytogenetic location: 2p25.1

Sources (4)

via Wikidata · CC0

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 2 G protein-coupled receptors