phenindamine
Sign in to saveAlso known as Nolahist, Phenindiamine, Thephorin, Fenindamina, Phenindaminum
Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. It was developed by Hoffman-La Roche in the late 1940s. It is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries; William S. Burroughs' book Junkie mentions this technique. Like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful
Research
70 papers- Phenindamine.2006
- The effects of phenindamine tartrate on sleepiness and psychomotor performance.The Journal of allergy and clinical immunology · 1992
- Determination of isophenindamine in phenindamine tartrate using an argentated high-performance liquid chromatographic mobile phase.Journal of pharmaceutical sciences · 1980
- Characterization of antihistamine-human serum protein interactions by capillary electrophoresis.Journal of chromatography. A · 2007
- Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats.Psychopharmacologia · 1976
via PubMed
Wikidata facts
- Mass
- 261.15175
Show 3 more facts
- chemical formula
- C₁₉H₁₉N
- Commons category
- Phenindamine
- canonical SMILES
- CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4
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Article
2 sectionsContents
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Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. It was developed by Hoffman-La Roche in the late 1940s. It is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries; William S. Burroughs' book Junkie mentions this technique. Like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful with those opioids which release histamine when in the body.
Nolahist was originally manufactured in the US by Carnrick Laboratories, and later by Amarin Pharmaceuticals. When that company ceased its American operations, its product line was acquired by Valeant, but they declined to resume manufacturing Nolahist. The last produced lot bore an expiration date of 10/2005, and the product is no longer available.