PPARGC1B

Also known as ERRL1, PERC, PGC-1(beta), PGC1B, PPARG coactivator 1 beta

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.

In the Vinony graph

Vinony's link graph records 51 inbound references to PPARGC1B, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It sits within the topics Gene expression, Genes on human chromosome 5 and Transcription coregulators.

Vinony links it to 6 Wikipedia language editions.

Gene data

PPARGC1B

Name: PPARG coactivator 1 beta
Type: protein-coding
Position: 149,729,994–149,855,022 (+)
Aliases: ERRL1, PERC, PGC-1(beta), PGC1B
Ensembl: ENSG00000155846
RefSeq RNA: NM_001172698.2, NM_001172699.2, NM_133263.4, XM_005268372.4, XM_011537553.3
RefSeq protein: NP_001166169.1, NP_001166170.1, NP_573570.3, XP_005268429.1, XP_011535855.1

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

Pathways

Insulin resistance - Homo sapiens (human)Developmental Biology Metabolism Mitochondrial biogenesis Mitochondrial biogenesis Organelle biogenesis and maintenance Organelle biogenesis and maintenance PPARA activates gene expression Epigenetic regulation of gene expression Epigenetic regulation of gene expression

via MyGene.info

Gene · Ensembl

PPARG coactivator 1 beta

Symbol: PPARGC1B
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:149,729,994-149,855,022
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 15776
genetic association: obesity
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/133522
genomic end: 149234585
genomic start: 149109861
chromosome: human chromosome 5
cytogenetic location: 5q32
expressed in: monocyte

Sources (5)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.

==See also== PPARGC1A Peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor delta Peroxisome proliferator-activated receptor gamma Transcription coregulator

Excerpted from Wikipedia’s “PPARGC1B” article, available under the CC BY-SA 4.0 licence.