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GeneQ18031206· pop 6· linked from 814 articles

RORB

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Also known as NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B, EIG15

gene umano

In the Vinony graph

Within Vinony's link graph, RORB is referenced by 814 other articles, and connects out to PubMed, human chromosome 9 and homeobox.

It is catalogued under topics including Genes on human chromosome 9, Intracellular receptors and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

RORB

Name: RAR related orphan receptor B
Type: protein-coding
Position: 74,497,329–74,693,177 (+)
Aliases: EIG15, NR1F2, ROR-BETA, RORbeta, RZR-BETA, RZRB, bA133M9.1
Ensembl: ENSG00000198963
RefSeq RNA: NM_001365023.1, NM_006914.4
RefSeq protein: NP_001351952.1, NP_008845.2

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II G protein-coupled receptor signaling pathway regulation of gene expression intracellular receptor signaling pathway amacrine cell differentiation eye photoreceptor cell development

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm nucleoplasm

Pathways

Circadian rhythm - Homo sapiens (human)Generic Transcription Pathway Nuclear Receptor transcription pathway RNA Polymerase II Transcription Gene expression (Transcription)Circadian clock Expression of BMAL (ARNTL), CLOCK, and NPAS2

via MyGene.info

Gene · Ensembl

RAR related orphan receptor B

Symbol: RORB
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:74,497,329-74,693,177
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein RORB PDB 1k4w.png

Show 9 more facts

HomoloGene ID: 38250
genetic association: generalized epilepsy
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6096
genomic end: 77308093
genomic start: 74497335
chromosome: human chromosome 9
cytogenetic location: 9q21.13
expressed in: endometrium

Sources (5)

via Wikidata · CC0

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 9 Intracellular receptors Transcription factors