SOX8

Also known as SRY-box 8, SRY-box transcription factor 8

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

Gene data

SOX8

Name: SRY-box transcription factor 8
Type: protein-coding
Position: 981,444–986,979 (+)
Ensembl: ENSG00000005513
RefSeq RNA: NM_014587.5
RefSeq protein: NP_055402.2

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II osteoblast differentiation

Article

3 sections

Contents

See also
References
Further reading

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the intellectual disability found in haemoglobin H-related mental retardation (ATR-16 syndrome).