SOX8

Also known as SRY-box 8, SRY-box transcription factor 8

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

In the Vinony graph

Within Vinony's link graph, SOX8 is referenced by 811 other articles, and connects out to PubMed, human chromosome 16 and homeobox.

It sits within the topics Genes on human chromosome 16 and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

SOX8

Name: SRY-box transcription factor 8
Type: protein-coding
Position: 981,444–986,979 (+)
Ensembl: ENSG00000005513
RefSeq RNA: NM_014587.5
RefSeq protein: NP_055402.2

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II osteoblast differentiation in utero embryonic development neural crest cell migration neural crest cell migration morphogenesis of an epithelium signal transduction signal transduction

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm transcription regulator complex cytoplasm

Pathways

Pre-implantation embryo Somatic sex determination Mammalian disorder of sexual development

via MyGene.info

Gene · Ensembl

SRY-box transcription factor 8

Symbol: SOX8
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:981,444-986,979
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 7950
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/30812
genomic end: 1036979
genomic start: 981770
chromosome: human chromosome 16
cytogenetic location: 16p13.3

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

See also
References
Further reading

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the intellectual disability found in haemoglobin H-related mental retardation (ATR-16 syndrome).

Excerpted from Wikipedia’s “SOX8” article, available under the CC BY-SA 4.0 licence.