SOX6

Name

SRY-box transcription factor 6

Type

protein-coding

Position

15,966,449–16,739,591 (−)

Aliases

HSSOX6, SOXD, TOLCAS

Ensembl

ENSG00000110693

RefSeq RNA

NM_001145811.2, NM_001145819.2, NM_001367872.1, NM_001367873.1, NM_017508.3

RefSeq protein

NP_001139283.1, NP_001139291.2, NP_001354801.1, NP_001354802.1, NP_059978.2

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].