TRPM5
Sign in to saveAlso known as LTRPC5, MTR1, transient receptor potential cation channel subfamily M member 5
Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.
In the Vinony graph
Within Vinony's link graph, TRPM5 is referenced by 312 other articles, and connects out to taste, PubMed and Ensembl genome database project.
It sits within the topics Genes on human chromosome 11 and Ion channels.
Its subject is documented across 4 Wikipedia language editions.
Gene data
TRPM5- Name
- transient receptor potential cation channel subfamily M member 5
- Type
- protein-coding
- Position
- 2,404,515–2,444,519 (−)
- Aliases
- LTRPC5, MTR1
- Ensembl
- ENSG00000070985
- RefSeq RNA
- NM_014555.4, XM_017017628.2, XM_047426858.1, XM_047426859.1, XM_054368597.1
- RefSeq protein
- NP_055370.1, XP_016873117.1, XP_047282814.1, XP_047282815.1, XP_054224572.1
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
transient receptor potential cation channel subfamily M member 5
- Symbol
- TRPM5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:2,404,515-2,444,519
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 22818
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29850
- genomic end
- 2444514
- genomic start
- 2425745
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.5
- Commons category
- TRPM5
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Function
- Drugs modulating TRPM5
- Agonists
- Antagonists
- See also
- References
- Further reading
- External links
Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.
== Function ==
Excerpted from Wikipedia’s “TRPM5” article, available under the CC BY-SA 4.0 licence.