TRPM8
Sign in to saveAlso known as LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).
Gene data
TRPM8- Name
- transient receptor potential cation channel subfamily M member 8
- Type
- protein-coding
- Aliases
- LTRPC6, LTrpC-6, TRPP8, trp-p8
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
transient receptor potential cation channel subfamily M member 8
- Symbol
- TRPM8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:233,917,373-234,019,522
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 23433
- genomic end
- 234928166
- exact match
- identifiers.org/ncbigene/79054
- genomic start
- 233917373
- cytogenetic location
- 2q37.1
- Commons category
- TRPM8
Sources (8)
via Wikidata · CC0
~11 min read
Article
17 sectionsContents
- Structure
- Function
- Role in the nervous system
- Properties
- pH-sensitivity
- Sensitization
- Desensitization
- Cross-desensitization
- Ligands
- Agonists
- Antagonists
- Clinical significance
- Role in cancer
- See also
- References
- Further reading
- External links
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).
== Structure == The TRPM8 channel is a homotetramer, composed of four identical subunits with a transmembrane domain with six helices (S1–6). The first four, S1–4, act as the voltage sensor and allow binding of menthol, icilin and similar channel agonists. S5 and S6 and a connecting loop, also part of the structure, make up the pore, a non-selective cation channel which consists of a highly conserved hydrophobic region. A range of diverse components are required for the high level of specificity in response to cold and menthol stimuli which eventually lead to ion flow through the protein channel.