ADGRG1

Also known as BFPP, BPPR, TM7LN4, TM7XN1, GPR56, adhesion G protein-coupled receptor G1

G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene. GPR56 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

In the Vinony graph

Vinony's link graph records 492 inbound references to ADGRG1, and connects out to Q180686, Ensembl genome database project and protein.

Vinony files it under Genes on human chromosome 16 and G protein-coupled receptors.

Vinony links it to 6 Wikipedia language editions.

Gene data

ADGRG1

Name: adhesion G protein-coupled receptor G1
Type: protein-coding
Position: 57,610,652–57,665,580 (+)
Aliases: BFPP, BPPR, CDCBM14B, CDCBM15A, GPR56, TM7LN4, TM7XN1
Ensembl: ENSG00000205336
RefSeq RNA: NM_001145770.3, NM_001145771.3, NM_001145772.3, NM_001145773.3, NM_001145774.3
RefSeq protein: NP_001139242.1, NP_001139243.1, NP_001139244.1, NP_001139245.1, NP_001139246.1

This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

Pathways

GPCRs, Other

via MyGene.info

Gene · Ensembl

adhesion G protein-coupled receptor G1

Symbol: ADGRG1
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:57,610,652-57,665,580
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4156
exact match: identifiers.org/ncbigene/9289
genomic start: 57644564
cytogenetic location: 16q21
genomic end: 57698944

Sources (5)

via Wikidata · CC0

~7 min read

Encyclopedic overview

6 sections

Contents

Ligands
Signaling
Function
Clinical significance
References
External links

GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells.

Excerpted from Wikipedia’s “ADGRG1” article, available under the CC BY-SA 4.0 licence.