DIDO1

Name

death inducer-obliterator 1

Type

protein-coding

Position

62,877,738–62,937,952 (−)

Aliases

BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8

Ensembl

ENSG00000101191

RefSeq RNA

NM_001193369.2, NM_001193370.2, NM_022105.5, NM_033081.3, NM_080796.4

RefSeq protein

NP_001180298.1, NP_001180299.1, NP_071388.2, NP_149072.2, NP_542986.1

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008].