EPHB6
Sign in to saveAlso known as HEP, EPH receptor B6
Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.
In the Vinony graph
Within Vinony's link graph, EPHB6 is referenced by 116 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 7 and Tyrosine kinase receptors.
Its subject is documented across 6 Wikipedia language editions.
Gene data
EPHB6- Name
- EPH receptor B6
- Type
- protein-coding
- Position
- 142,854,809–142,872,810 (+)
- Aliases
- HEP
- Ensembl
- ENSG00000106123
- RefSeq RNA
- NM_001280794.3, NM_001280795.2, NM_004445.6, NR_104001.2, XM_011515879.2
- RefSeq protein
- NP_001267723.2, NP_001267724.2, NP_004436.4, XP_011514181.1, XP_011514182.1
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
EPH receptor B6
- Symbol
- EPHB6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:142,854,809-142,872,810
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 20940
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2051
- chromosome
- human chromosome 7
- genomic start
- 142552792
- genomic end
- 142568847
- cytogenetic location
- 7q34
- expressed in
- prefrontal cortex
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
Excerpted from Wikipedia’s “EPHB6” article, available under the CC BY-SA 4.0 licence.
Available in 6 languages
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