KALRN
Sign in to saveAlso known as ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin, RhoGEF kinase
Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1. Is also known to play an important role in nerve growth and axonal development.
In the Vinony graph
Within Vinony's link graph, KALRN is referenced by 308 other articles, and connects out to Wikidata, PubMed and Ensembl genome database project.
It sits within the topics EC 2.7.11, Genes on human chromosome 3 and GTP-binding protein regulators.
Its subject is documented across 7 Wikipedia language editions.
Gene data
KALRN- Name
- kalirin RhoGEF kinase
- Type
- protein-coding
- Position
- 124,033,310–124,726,325 (+)
- Aliases
- ARHGEF24, CHDS5, DUET, DUO, HAPIP, KALNC2, TRAD
- Ensembl
- ENSG00000160145
- RefSeq RNA
- NM_001024660.5, NM_001322988.2, NM_001322989.2, NM_001322990.2, NM_001322991.2
- RefSeq protein
- NP_001019831.2, NP_001309917.1, NP_001309918.1, NP_001309919.1, NP_001309920.1
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
kalirin RhoGEF kinase
- Symbol
- KALRN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:124,033,310-124,726,325
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 14 more facts
- HomoloGene ID
- 57160
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8997
- genomic end
- 124445172
- genomic start
- 124033369
- chromosome
- human chromosome 3
- cytogenetic location
- 3q21.1-q21.2
- genetic association
- intellectual disability
- expressed in
- dorsolateral prefrontal cortex
- gene substitution association with
- schizophrenia
- decreased expression in
- stroke
- increased expression in
- coronary artery disease
- altered regulation leads to
- addiction
- Commons category
- Kalirin
Sources (4)
via Wikidata · CC0
~8 min read
Encyclopedic overview
6 sectionsContents
- Clinical significance
- Function
- Expression
- Notes
- References
- External links
Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1. Is also known to play an important role in nerve growth and axonal development.
Kalirin is a member of the Dbl family of proteins and is a Rho guanine nucleotide exchange factor.
Excerpted from Wikipedia’s “KALRN” article, available under the CC BY-SA 4.0 licence.