PRKAA2

Name

protein kinase AMP-activated catalytic subunit alpha 2

Type

protein-coding

Position

56,645,314–56,715,335 (+)

Aliases

AMPK, AMPK2, AMPKa2, PRKAA

Ensembl

ENSG00000162409

RefSeq RNA

NM_006252.4, XM_017001693.2, XM_054337539.1

RefSeq protein

NP_006243.2, XP_016857182.1, XP_054193514.1

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

protein kinase AMP-activated catalytic subunit alpha 2

Symbol

PRKAA2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:56,645,206-56,715,335

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein PRKAA2 PDB 2h6d.png

via Wikidata · CC0